2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-123667
    NCFP 774548-65-1 98%
    NCFP is a metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (PAM). NCFP can be used in the study of central nervous system diseases.
    NCFP
  • HY-12366R
    Ubrogepant (Standard) 1374248-77-7
    Ubrogepant (Standard) is the analytical standard of Ubrogepant. This product is intended for research and analytical applications. Ubrogepant (MK-1602) is an orally active and selective antagonist of calcitonin gene-related peptide receptor (CGRP). Ubrogepant has high affinity for CGRP receptors in human and rhesus monkeys, and can effectively block the cAMP response stimulated by α-CGRP. Ubrogepant can be used in the study of acute migraine.
    Ubrogepant (Standard)
  • HY-12366S
    Ubrogepant-d5 98%
    Ubrogepant-d5 (MK-1602-d5) is deuterium labeled Ubrogepant. Ubrogepant (MK-1602) is an orally active and selective antagonist of calcitonin gene-related peptide receptor (CGRP). Ubrogepant has high affinity for CGRP receptors in human and rhesus monkeys, and can effectively block the cAMP response stimulated by α-CGRP. Ubrogepant can be used in the study of acute migraine.
    Ubrogepant-d5
  • HY-123676
    Sonepiprazole mesylate 170858-34-1 98%
    Sonepiprazole mesylate is a selective D4 dopamine antagonist with Kis of 3.6, 10.1, 5147, and 7430 nM for rD4-Dopamine, hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 receptors, respectively.
    Sonepiprazole mesylate
  • HY-123737
    MK-8133 1431472-56-8 98%
    MK-8133 is an orexin-2 receptor antagonist. MK-8133 can be used in the study of insomnia.
    MK-8133
  • HY-123747
    SC-53116 141196-99-8 98%
    SC-53116 is a selective 5-HT4 receptor agonist with EC50 at 23 nM.
    SC-53116
  • HY-123757
    (Rac)-GR218231 175442-95-2 98%
    (Rac)-GR218231 is a selective dopamine D3 receptor antagonist with a pKi of 8.9.
    (Rac)-GR218231
  • HY-123788
    BRD5814 1953181-29-7 98%
    BRD5814 is a D2R antagonist. BRD5814 can be used in schizophrenia research.
    BRD5814
  • HY-12380R
    Atipamezole hydrochloride (Standard) 104075-48-1 98%
    Atipamezole (hydrochloride) (Standard) is the analytical standard of Atipamezole (hydrochloride). This product is intended for research and analytical applications. Atipamezole (MPV-1248) hydrochloride is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM.
    Atipamezole hydrochloride (Standard)
  • HY-12383R
    Pelubiprofen (Standard) 69956-77-0 98%
    Pelubiprofen (Standard) is the analytical standard of Pelubiprofen. This product is intended for research and analytical applications. Pelubiprofen is an orally active anti-inflammatory agent that inhibits COX enzyme activity (with IC50 values of 10.66 and 2.88 μM for COX-1 and COX-2, respectively). Pelubiprofen has significant anti-inflammatory and analgesic effects.
    Pelubiprofen (Standard)
  • HY-12388S
    N-Desmethyl clomipramine-d7 98%
    N-Desmethyl clomipramine-d7 (Desmethylclomipramine-d7) is deuterium labeled N-Desmethyl clomipramine. Desmethylclomipramine (Norclomipramine) is a metabolite of Clomipramine (HY-B0457A) and can be used for neurological research.
    N-Desmethyl clomipramine-d7
  • HY-123904
    UoS12258 875927-64-3 99.86%
    UoS12258 is a selective positive allosteric modulator of AMPA receptor. UoS12258 enhances AMPA receptor‐mediated synaptic transmission. UoS12258 improves performance in cognition rat models, including Scopolamine (HY-N0296)‐impaired rats and water maze learning and retention in aged rats.
    UoS12258
  • HY-12390R
    Lofepramine (Standard) 23047-25-8 98%
    Lofepramine (Standard) is the analytical standard of Lofepramine. This product is intended for research and analytical applications. Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) (HY-13715) and 5-hydroxytryptamine (5-HT) with IC50s of 2.7 μM and 11 μM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. .
    Lofepramine (Standard)
  • HY-12390S
    Lofepramine-d3 1185083-78-6 98%
    Lofepramine-d3 (Lopramine-d3) is the deuterium labeled Lofepramine. Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties.
    Lofepramine-d3
  • HY-12392R
    Iprindole (Standard) 5560-72-5 98%
    Iprindole (Standard) is the analytical standard of Iprindole. This product is intended for research and analytical applications. Iprindole, an opioid receptor agonist, is a tricyclic antidepressant. Iprindole shortens the immobility time in mice forced swimming test, which can be reversed by the opiate antagonist Naloxone (HY-17417A). Iprindole induces lamellar body formation but devoid of lamellar bodies. Iprindole hydrochloride can be used for the research of depression.
    Iprindole (Standard)
  • HY-123934
    VU6007477 2220141-46-6 98%
    VU6007477 is a brain-penetrant, selective M1 positive allosteric modulator (PAM) with an EC50 value of 230 nM. VU6007477 is also a human P-glycoprotein (P-gp) substrate with moderate permeability. VU6007477 displays improved central nervous system (CNS) penetration over the hydroxylated congeners. VU6007477 a pyranyl amide derivative, which is promising for research of robust cholinergic seizure activity.
    VU6007477
  • HY-124173
    PF-06815189 2218484-75-2 98%
    PF-06815189 is a phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 0.4 nM.
    PF-06815189
  • HY-124217
    Prolintane hydrochloride 1211-28-5 98%
    Prolintane hydrochloride, an amphetaminea, is a psychoactive compound.
    Prolintane hydrochloride
  • HY-124225
    RU 33965 122321-05-5 98%
    RU 33965 is an orally active benzodiazepine receptor weak partial inverse agonist.
    RU 33965
  • HY-124232
    BTG 502 99083-11-1 98%
    BTG 502 is an alkylamide insecticide. BTG 502 can reduce sodium current and antagonize the effect of bat toxin (BTX) on cockroach sodium channels.
    BTG 502
Cat. No. Product Name / Synonyms Application Reactivity